About Us

LARGE-PD

The Latin American Research consortium on the GEnetics of Parkinson’s Disease (LARGE-PD) was born in 2005 as a multicenter collaboration across Latin America in an effort to increase the knowledge about PD in these countries.

Human Genetics as well as epidemiological studies have proven to be valuable tools for the better understanding of the molecular pathophysiology of PD.  This Consortium is generating the first large PD case-control sample in Latin America that will allow digging deep into these genetic and environmental factors that lead to the development of Parkinson’s disease.

We believe that including these representative populations will substantially increase the likelihood of discovering new susceptibility genes for the disease. Additional benefits from this approach include: (1) providing a more rational basis for the selection of mutations for clinical genetic testing within specific geographic regions, and (2) identifying subgroups of individuals at high-risk for PD who would be good candidates for future neuroprotective trials (possibly based on genetic profile).

At the present time, the Consortium is composed of recruitment sites at six major academic centers in 5 different countries (Argentina, Brazil, Colombia, Peru and Uruguay). Dr Mata and Dr Zabetian, at the VA Puget Sound and the University of Washington in Seattle serve as the coordinators for the Consortium, ensuring standardized data collection, DNA storage and quality control.

By February of 2012 it is projected that the sites will have data and DNA collected for at least 1,750 patients and 1,650 controls.

We are actively searching for new sites in these or other countries in Latin America. If you are interested please contact us (link).

Aims:

  1. The major aim is to establish a multicenter PD genetics consortium across Latin America. Patients and controls will be enrolled across each site using uniform diagnostic criteria and data collection procedures.
  2. We are also interested in collecting multiplex PD families (with several affected individuals)
  3. Help improving research in each of the participant institutions
  4. Help acquiring Institutional Review Board (IRB) and Federal Wide Assurance (FWA) permission to perform International research for all participating sites.
  5. Promote the training of researchers by encouraging the exchange of knowledge in annual meetings, website, and exchange of researchers between sites.
  6. Design and submission of research projects to search for funding both nationally and internationally

 

Data Collection:

A LARGE-PD form has been developed to assure standardization of the data collection (available upon request). This form collects clinical, demographic and environmental exposure data for each individual (key elements are summarized in Table).

 

Determined by movement disorder specialist

  • Determination of eligibility and presence/absence of individual elements of the UKPDSBB Criteria
  • Presence of dyskinesias & rating of intensity/duration
  • Hoehn & Yahr Stage
  • Presence/absence of dementia
  • Presence/absence of psychosis

Collected by nurse coordinator

  • Age at onset (of first symptoms from UKPDSBB Criteria, Step 1)
  • Focused past medical history
  • Age at first diagnosis of PD
  • Self-administered questionnaire on lifetime smoking, caffeine, & non-steroidal anti-inflammatory drug use
  • Presenting symptom (of parkinsonism) & location
  • Ancestry of subject & parents
  • Current/previous antiparkinsonian medications & duration of therapy
  • Family history of PD & pedigree diagram

 

LARGE-PD CENTERS

–          Instituto Nacional de Ciencias Neurológicas, Lima, Peru

–          Instituto de Neurología, Universidad de la Republica, Montevideo, Uruguay

–          Hospital de Clínicas, Facultad de Medicina, Buenos Aires, Argentina

–          Departamento da Neurologia, Universidade Federal da São Paulo, São Paulo, Brazil

–          Facultade da Medicina da Ribeirão Preto-Universidade Federal de São Paulo, Ribeirão Preto, Brazil

–          Universidad de Antioquia, Medellín, Colombia

–          Geriatric Research Education and Clinical Center (VA Puget Sound Health Care System) and Department of Neurology (University of Washington), Seattle, USA

 

CONTACT

Ignacio F. Mata, PhD

University of Washington, Department of Neurology

Geriatric Research Education and Clinical Center S-182

VA Puget Sound Health Care System

1660 South Columbian Way

Seattle, WA 98108.

Phone: +1 (206) 277-6590

Fax: +1 (206) 764-2569

E-mail: nachofm[at]uw.edu

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